Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	RAG2	HGNC:9832 (HGNC) 5897 (Entrez Gene) 179616 (OMIM) RAG2 (Alliance of Genome Resources)	Chr11 p12	Chr11:36575574-36598279 (-) GRCh38	combined cellular and humoral immune defects with granulomas Omenn syndrome severe combined immunodeficiency severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive	P55895 (UniProt | EBI) NM_001243785 (RefSeq)
mouse	Rag2	MGI:97849 (MGI) 19374 (Entrez Gene) Gene Tree Rag2 (Alliance of Genome Resources)	Chr2 53.87 cM	Chr2:101455063-101462874 (+) GRCm39	Omenn syndrome severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive	ENSMUSG00000032864 (Ensembl Gene Model) ENSMUSP00000038204 (Ensembl) ENSMUST00000044031 (Ensembl)
rat	Rag2	RGD:1305588 (Rat Genome Database) 295953 (Entrez Gene) Rag2 (Alliance of Genome Resources)	Chr3 q31			NP_001093998 (RefSeq) NM_001100528 (RefSeq)
zebrafish	rag2	ZDB-GENE-990415-235 (Zebrafish Model Organism Database) 30658 (Entrez Gene) rag2 (Alliance of Genome Resources)	Chr25			O13034 (UniProt | EBI) NM_131385 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.