Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	TP53	HGNC:11998 (HGNC) 7157 (Entrez Gene) 191170 (OMIM) TP53 (Alliance of Genome Resources)	Chr17 p13.1	Chr17:7661779-7687546 (-) GRCh38	acute myeloid leukemia basal cell carcinoma B-lymphoblastic leukemia/lymphoma breast cancer choroid plexus papilloma colorectal cancer colorectal carcinoma coronary artery disease coronary restenosis endometrial adenocarcinoma esophagus squamous cell carcinoma gastric adenocarcinoma Graves' disease hematologic cancer hepatocellular carcinoma high grade glioma Leber hereditary optic neuropathy Li-Fraumeni syndrome Li-Fraumeni syndrome 1 low tension glaucoma melanoma mismatch repair cancer syndrome multiple myeloma myelodysplastic syndrome nasal cavity cancer nasopharynx carcinoma oral squamous cell carcinoma osteosarcoma ovary serous adenocarcinoma pancreatic cancer pancreatic intraductal papillary-mucinous neoplasm papillary thyroid carcinoma paranasal sinus benign neoplasm primary open angle glaucoma prostate cancer sarcoma squamous cell carcinoma stomach cancer	P04637 (UniProt | EBI) NM_001126112 (RefSeq)
mouse	Trp53	MGI:98834 (MGI) 22059 (Entrez Gene) Gene Tree Trp53 (Alliance of Genome Resources)	Chr11 42.83 cM	Chr11:69471185-69482699 (+) GRCm39	breast cancer CHARGE syndrome diffuse large B-cell lymphoma dyskeratosis congenita endometrial cancer glioblastoma Li-Fraumeni syndrome osteosarcoma	ENSMUSG00000059552 (Ensembl Gene Model) ENSMUSP00000104298 (Ensembl) ENSMUST00000108658 (Ensembl)
rat	Tp53	RGD:3889 (Rat Genome Database) 24842 (Entrez Gene) Tp53 (Alliance of Genome Resources)	Chr10 q24			P10361 (UniProt | EBI) NM_001429996 (RefSeq)
zebrafish	tp53	ZDB-GENE-990415-270 (Zebrafish Model Organism Database) 30590 (Entrez Gene) tp53 (Alliance of Genome Resources)	Chr5			P79734 (UniProt | EBI) NM_001328587 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.