Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	GDF5	HGNC:4220 (HGNC) 8200 (Entrez Gene) 601146 (OMIM) GDF5 (Alliance of Genome Resources)	Chr20 q11.22	Chr20:35433347-35454749 (-) GRCh38	acromesomelic dysplasia, Grebe type acromesomelic dysplasia, Hunter-Thompson type brachydactyly type A1 brachydactyly type A1C brachydactyly type A2 brachydactyly type C developmental dysplasia of the hip 1 fibular hypoplasia and complex brachydactyly multiple synostoses syndrome 1 multiple synostoses syndrome 2 osteoarthritis Parkinson's disease proximal symphalangism 2	P43026 (UniProt | EBI) NM_000557 (RefSeq)
mouse	Gdf5	MGI:95688 (MGI) 14563 (Entrez Gene) Gene Tree Gdf5 (Alliance of Genome Resources)	Chr2 77.26 cM	Chr2:155782943-155787204 (-) GRCm39	acromesomelic dysplasia, Grebe type acromesomelic dysplasia, Hunter-Thompson type brachydactyly type A1C brachydactyly type A2 brachydactyly type C fibular hypoplasia and complex brachydactyly multiple synostoses syndrome osteoarthritis	14563 (NCBI Gene Model) P43027 (UniProt | EBI) NM_008109 (RefSeq)
rat	Gdf5	RGD:620102 (Rat Genome Database) 252835 (Entrez Gene) Gdf5 (Alliance of Genome Resources)	Chr3			NP_001385590 (RefSeq) NM_001398661 (RefSeq)
zebrafish	gdf5	ZDB-GENE-990415-39 (Zebrafish Model Organism Database) 100334210 (Entrez Gene) gdf5 (Alliance of Genome Resources)	Chr6			XP_002662587 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.