Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SMAD2	HGNC:6768 (HGNC) 4087 (Entrez Gene) 601366 (OMIM) SMAD2 (Alliance of Genome Resources)	Chr18 q21.1	Chr18:47808957-47931146 (-) GRCh38	cervical cancer Loeys-Dietz syndrome 6 Lynch syndrome ovarian cancer	Q15796 (UniProt | EBI) NM_001135937 (RefSeq)
mouse	Smad2	MGI:108051 (MGI) 17126 (Entrez Gene) Gene Tree Smad2 (Alliance of Genome Resources)	Chr18 51.42 cM	Chr18:76374651-76444034 (+) GRCm39		ENSMUSG00000024563 (Ensembl Gene Model) ENSMUSP00000130115 (Ensembl) ENSMUST00000168423 (Ensembl)
rat	Smad2	RGD:3031 (Rat Genome Database) 29357 (Entrez Gene) Smad2 (Alliance of Genome Resources)	Chr18 q12.3			O70436 (UniProt | EBI) NM_001277450 (RefSeq)
zebrafish	smad2	ZDB-GENE-990603-7 (Zebrafish Model Organism Database) 30639 (Entrez Gene) smad2 (Alliance of Genome Resources)	Chr10			Q9I9P9 (UniProt | EBI) NM_131366 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.