Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SMAD4	HGNC:6770 (HGNC) 4089 (Entrez Gene) 600993 (OMIM) SMAD4 (Alliance of Genome Resources)	Chr18 q21.2	Chr18:51028528-51085045 (+) GRCh38	aortic disease endometrial carcinoma gastrointestinal system cancer hereditary hemorrhagic telangiectasia juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome juvenile polyposis syndrome Lynch syndrome ovarian cancer pancreatic cancer seminoma	Q13485 (UniProt | EBI) NM_001407043 (RefSeq)
mouse	Smad4	MGI:894293 (MGI) 17128 (Entrez Gene) Gene Tree Smad4 (Alliance of Genome Resources)	Chr18 49.51 cM	Chr18:73772080-73836851 (-) GRCm39	juvenile polyposis syndrome osteogenesis imperfecta	ENSMUSG00000024515 (Ensembl Gene Model) ENSMUSP00000025393 (Ensembl) ENSMUST00000025393 (Ensembl)
rat	Smad4	RGD:3033 (Rat Genome Database) 50554 (Entrez Gene) Smad4 (Alliance of Genome Resources)	Chr18 q12.2			O70437 (UniProt | EBI) NM_019275 (RefSeq)
zebrafish	smad4a	ZDB-GENE-990603-8 (Zebrafish Model Organism Database) 559111 (Entrez Gene) smad4a (Alliance of Genome Resources)	Chr10			NP_001116172 (RefSeq) NM_001122700 (RefSeq)
	smad4b	ZDB-GENE-060130-140 (Zebrafish Model Organism Database) 794669 (Entrez Gene) smad4b (Alliance of Genome Resources)	Chr5			XP_009299441 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.