Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	TCF7L2	HGNC:11641 (HGNC) 6934 (Entrez Gene) 602228 (OMIM) TCF7L2 (Alliance of Genome Resources)	Chr10 q25.2-q25.3	Chr10:112950247-113167678 (+) GRCh38	breast cancer colorectal cancer diabetes mellitus gestational diabetes pancreatic cancer prostate cancer type 2 diabetes mellitus	Q9NQB0 (UniProt | EBI) NM_001198528 (RefSeq)
mouse	Tcf7l2	MGI:1202879 (MGI) 21416 (Entrez Gene) Gene Tree Tcf7l2 (Alliance of Genome Resources)	Chr19 51.59 cM	Chr19:55730252-55922086 (+) GRCm39		ENSMUSG00000024985 (Ensembl Gene Model) ENSMUSP00000107284 (Ensembl) ENSMUST00000111657 (Ensembl)
rat	Tcf7l2	RGD:1583621 (Rat Genome Database) 679869 (Entrez Gene) Tcf7l2 (Alliance of Genome Resources)	Chr1 q55			NP_001402734 (RefSeq) NM_001415805 (RefSeq)
zebrafish	tcf7l2	ZDB-GENE-991110-8 (Zebrafish Model Organism Database) 30510 (Entrez Gene) tcf7l2 (Alliance of Genome Resources)	Chr12			NP_571334 (RefSeq) NM_131259 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.