Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	PSEN1	HGNC:9508 (HGNC) 5663 (Entrez Gene) 104311 (OMIM) PSEN1 (Alliance of Genome Resources)	Chr14 q24.2	Chr14:73136417-73223691 (+) GRCh38	Alzheimer's disease Alzheimer's disease 3 dilated cardiomyopathy 1U frontotemporal dementia hidradenitis suppurativa Pick's disease	P49768 (UniProt | EBI) NM_007319 (RefSeq)
mouse	Psen1	MGI:1202717 (MGI) 19164 (Entrez Gene) Gene Tree Psen1 (Alliance of Genome Resources)	Chr12 38.84 cM	Chr12:83734926-83781869 (+) GRCm39	Alzheimer's disease Alzheimer's disease 3	19164 (NCBI Gene Model) P49769 (UniProt | EBI) NM_001362271 (RefSeq)
rat	Psen1	RGD:3425 (Rat Genome Database) 29192 (Entrez Gene) Psen1 (Alliance of Genome Resources)	Chr6 q31			P97887 (UniProt | EBI) NM_019163 (RefSeq)
zebrafish	psen1	ZDB-GENE-991119-4 (Zebrafish Model Organism Database) 30221 (Entrez Gene) psen1 (Alliance of Genome Resources)	Chr17			Q9W6T7 (UniProt | EBI) NM_131024 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.