Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	TOP1	HGNC:11986 (HGNC) 7150 (Entrez Gene) 126420 (OMIM) TOP1 (Alliance of Genome Resources)	Chr20 q12	Chr20:41028822-41124487 (+) GRCh38		P11387 (UniProt | EBI) NM_003286 (RefSeq)
mouse	Top1	MGI:98788 (MGI) 21969 (Entrez Gene) Gene Tree Top1 (Alliance of Genome Resources)	Chr2 80.96 cM	Chr2:160487901-160564684 (+) GRCm39		21969 (NCBI Gene Model) Q04750 (UniProt | EBI) NM_009408 (RefSeq)
rat	Top1	RGD:621246 (Rat Genome Database) 64550 (Entrez Gene) Top1 (Alliance of Genome Resources)	Chr3 q42			Q9WUL0 (UniProt | EBI) NM_022615 (RefSeq)
zebrafish	top1a	ZDB-GENE-060616-217 (Zebrafish Model Organism Database) 553496 (Entrez Gene) top1a (Alliance of Genome Resources)	Chr11			NP_001037789 (RefSeq) NM_001044324 (RefSeq)
	top1b	ZDB-GENE-030131-5390 (Zebrafish Model Organism Database) 327179 (Entrez Gene) top1b (Alliance of Genome Resources)	Chr23			XP_002666448 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.