Vertebrate Homology

• Source: Alliance of Genome Resources

Comparative GO Graph (mouse, human, rat)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	DEFA1	HGNC:2761 (HGNC) 1667 (Entrez Gene) 125220 (OMIM) DEFA1 (Alliance of Genome Resources)	Chr8 p23.1	Chr8:6977649-6980092 (-) GRCh38		P59665 (UniProt | EBI) NM_004084 (RefSeq)
	DEFA1B	HGNC:33596 (HGNC) 728358 (Entrez Gene) DEFA1B (Alliance of Genome Resources)	Chr8 p23.1	Chr8:6996766-6999198 (-) GRCh38		P59665 (UniProt | EBI) NM_001042500 (RefSeq)
	DEFA3	HGNC:2762 (HGNC) 1668 (Entrez Gene) 604522 (OMIM) DEFA3 (Alliance of Genome Resources)	Chr8 p23.1	Chr8:7015869-7018297 (-) GRCh38		P59666 (UniProt | EBI) NM_005217 (RefSeq)
	DEFA4	HGNC:2763 (HGNC) 1669 (Entrez Gene) 601157 (OMIM) DEFA4 (Alliance of Genome Resources)	Chr8 p23.1	Chr8:6935820-6938306 (-) GRCh38		P12838 (UniProt | EBI) NM_001925 (RefSeq)
	DEFA6	HGNC:2765 (HGNC) 1671 (Entrez Gene) 600471 (OMIM) DEFA6 (Alliance of Genome Resources)	Chr8 p23.1	Chr8:6924697-6926076 (-) GRCh38		Q01524 (UniProt | EBI) NM_001926 (RefSeq)
mouse	Defa4	MGI:99584 (MGI) 13238 (Entrez Gene) Defa4 (Alliance of Genome Resources)	Chr8 Syntenic			AF178040 (GenBank | ENA | DDBJ) P28311 (UniProt | EBI) NM_010039 (RefSeq)
rat	Defa24	RGD:1304852 (Rat Genome Database) 290856 (Entrez Gene) Defa24 (Alliance of Genome Resources)	Chr16 q12.5			P82106 (UniProt | EBI) NM_001013053 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.