Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	GFRA1	HGNC:4243 (HGNC) 2674 (Entrez Gene) 601496 (OMIM) GFRA1 (Alliance of Genome Resources)	Chr10 q25.3	Chr10:116056925-116276803 (-) GRCh38	renal agenesis	P56159 (UniProt | EBI) NM_001382557 (RefSeq)
mouse	Gfra1	MGI:1100842 (MGI) 14585 (Entrez Gene) Gene Tree Gfra1 (Alliance of Genome Resources)	Chr19 54.18 cM	Chr19:58224036-58444341 (-) GRCm39	Hirschsprung's disease	ENSMUSG00000025089 (Ensembl Gene Model) ENSMUSP00000026076 (Ensembl) ENSMUST00000026076 (Ensembl)
rat	Gfra1	RGD:2681 (Rat Genome Database) 25454 (Entrez Gene) Gfra1 (Alliance of Genome Resources)	Chr1 q55			Q62997 (UniProt | EBI) NM_012959 (RefSeq)
zebrafish	gfra1a	ZDB-GENE-010226-2 (Zebrafish Model Organism Database) 79376 (Entrez Gene) gfra1a (Alliance of Genome Resources)	Chr13			NP_571805 (RefSeq) NM_131730 (RefSeq)
	gfra1b	ZDB-GENE-010226-3 (Zebrafish Model Organism Database) 79377 (Entrez Gene) gfra1b (Alliance of Genome Resources)	Chr12			NP_571806 (RefSeq) NM_131731 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.