Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	PTPN11	HGNC:9644 (HGNC) 5781 (Entrez Gene) 176876 (OMIM) PTPN11 (Alliance of Genome Resources)	Chr12 q24.13	Chr12:112418351-112509918 (+) GRCh38	atrophic gastritis chondroma juvenile myelomonocytic leukemia metachondromatosis Noonan syndrome Noonan syndrome 1 Noonan syndrome with multiple lentigines 1 stomach cancer tetralogy of Fallot	Q06124 (UniProt | EBI) NM_018508 (RefSeq)
mouse	Ptpn11	MGI:99511 (MGI) 19247 (Entrez Gene) Gene Tree Ptpn11 (Alliance of Genome Resources)	Chr5 61.72 cM	Chr5:121268596-121329460 (-) GRCm39	dilated cardiomyopathy disease of metabolism hepatocellular adenoma hypertrophic cardiomyopathy idiopathic scoliosis juvenile myelomonocytic leukemia Noonan syndrome 1 Noonan syndrome with multiple lentigines	19247 (NCBI Gene Model) P35235 (UniProt | EBI) NM_011202 (RefSeq)
rat	Ptpn11	RGD:3447 (Rat Genome Database) 25622 (Entrez Gene) Ptpn11 (Alliance of Genome Resources)	Chr12 q16			P41499 (UniProt | EBI) NM_013088 (RefSeq)
zebrafish	ptpn11a	ZDB-GENE-030131-5911 (Zebrafish Model Organism Database) 333979 (Entrez Gene) ptpn11a (Alliance of Genome Resources)	Chr10			NP_956140 (RefSeq) NM_199846 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.