Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	PITX2	HGNC:9005 (HGNC) 5308 (Entrez Gene) 601542 (OMIM) PITX2 (Alliance of Genome Resources)	Chr4 q25	Chr4:110617423-110642123 (-) GRCh38	anterior segment dysgenesis 4 Arts syndrome Axenfeld-Rieger syndrome Axenfeld-Rieger syndrome type 1 ring dermoid of cornea	Q99697 (UniProt | EBI) NM_153427 (RefSeq)
mouse	Pitx2	MGI:109340 (MGI) 18741 (Entrez Gene) Gene Tree Pitx2 (Alliance of Genome Resources)	Chr3 57.84 cM	Chr3:128993527-129013240 (+) GRCm39	Axenfeld-Rieger syndrome type 1 glaucoma	ENSMUSG00000028023 (Ensembl Gene Model) ENSMUSP00000047359 (Ensembl) ENSMUST00000042587 (Ensembl)
rat	Pitx2	RGD:3331 (Rat Genome Database) 54284 (Entrez Gene) Pitx2 (Alliance of Genome Resources)	Chr2 q42			Q9R0W1 (UniProt | EBI) NM_019334 (RefSeq)
zebrafish	pitx2	ZDB-GENE-990714-27 (Zebrafish Model Organism Database) 30164 (Entrez Gene) pitx2 (Alliance of Genome Resources)	Chr14			Q9W5Z2 (UniProt | EBI) NM_130975 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.