Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	NOS3	HGNC:7876 (HGNC) 4846 (Entrez Gene) 163729 (OMIM) NOS3 (Alliance of Genome Resources)	Chr7 q36.1	Chr7:150991017-151014588 (+) GRCh38	acute chest syndrome acute lymphoblastic leukemia acute myeloid leukemia Alzheimer's disease angle-closure glaucoma anterior ischemic optic neuropathy asthma atherosclerosis Behcet's disease breast cancer cardiomyopathy coronary artery disease cystic fibrosis diabetic retinopathy end stage renal disease esophagus adenocarcinoma essential hypertension hypertension Kuhnt-Junius degeneration limb ischemia macular retinal edema migraine myocardial infarction nephritis obstructive sleep apnea osteonecrosis ovarian cancer primary open angle glaucoma prostate cancer pulmonary hypertension respiratory allergy retinopathy of prematurity sickle cell anemia telangiectasis vasculitis vulva cancer	P29474 (UniProt | EBI) NM_000603 (RefSeq)
mouse	Nos3	MGI:97362 (MGI) 18127 (Entrez Gene) Gene Tree Nos3 (Alliance of Genome Resources)	Chr5 11.32 cM	Chr5:24569808-24589472 (+) GRCm39	aortic valve disease essential hypertension persistent fetal circulation syndrome	ENSMUSG00000028978 (Ensembl Gene Model) ENSMUSP00000030834 (Ensembl) ENSMUST00000030834 (Ensembl)
rat	Nos3	RGD:3186 (Rat Genome Database) 24600 (Entrez Gene) Nos3 (Alliance of Genome Resources)	Chr4 q11			Q62600 (UniProt | EBI) NM_021838 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.