Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	KRT6A	HGNC:6443 (HGNC) 3853 (Entrez Gene) 148041 (OMIM) KRT6A (Alliance of Genome Resources)	Chr12 q13.13	Chr12:52487176-52493257 (-) GRCh38	pachyonychia congenita	P02538 (UniProt | EBI) NM_005554 (RefSeq)
	KRT6B	HGNC:6444 (HGNC) 3854 (Entrez Gene) 148042 (OMIM) KRT6B (Alliance of Genome Resources)	Chr12 q13.13	Chr12:52446651-52452146 (-) GRCh38	pachyonychia congenita	P04259 (UniProt | EBI) NM_005555 (RefSeq)
	KRT6C	HGNC:20406 (HGNC) 286887 (Entrez Gene) 612315 (OMIM) KRT6C (Alliance of Genome Resources)	Chr12 q13.13	Chr12:52468516-52473805 (-) GRCh38	focal or diffuse nonepidermolytic palmoplantar keratoderma	P48668 (UniProt | EBI) NM_173086 (RefSeq)
mouse	Gm5478	MGI:3646318 (MGI) 432987 (Entrez Gene) Gene Tree Gm5478 (Alliance of Genome Resources)	Chr15 56.95 cM	Chr15:101551455-101555815 (-) GRCm39		ENSMUSG00000095241 (Ensembl Gene Model) ENSMUSP00000155269 (Ensembl) ENSMUST00000229963 (Ensembl)
zebrafish	krt4	ZDB-GENE-000607-83 (Zebrafish Model Organism Database) 794486 (Entrez Gene) krt4 (Alliance of Genome Resources)	Chr6			NP_571584 (RefSeq) NM_131509 (RefSeq)
	krt5	ZDB-GENE-991110-23 (Zebrafish Model Organism Database) 797351 (Entrez Gene) krt5 (Alliance of Genome Resources)	Chr23			NP_571231 (RefSeq) NM_131156 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.