Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SCN8A	HGNC:10596 (HGNC) 6334 (Entrez Gene) 600702 (OMIM) SCN8A (Alliance of Genome Resources)	Chr12 q13.13	Chr12:51590266-51812864 (+) GRCh38	benign familial infantile seizures 5 developmental and epileptic encephalopathy 13	Q9UQD0 (UniProt | EBI) NM_014191 (RefSeq)
mouse	Scn8a	MGI:103169 (MGI) 20273 (Entrez Gene) Gene Tree Scn8a (Alliance of Genome Resources)	Chr15 56.39 cM	Chr15:100767739-100943819 (+) GRCm39	early infantile epileptic encephalopathy epilepsy	ENSMUSG00000023033 (Ensembl Gene Model) ENSMUSP00000104537 (Ensembl) ENSMUST00000108909 (Ensembl)
rat	Scn8a	RGD:3638 (Rat Genome Database) 29710 (Entrez Gene) Scn8a (Alliance of Genome Resources)	Chr7 q36			O88420 (UniProt | EBI) NM_019266 (RefSeq)
zebrafish	scn8aa	ZDB-GENE-000828-1 (Zebrafish Model Organism Database) 58152 (Entrez Gene) scn8aa (Alliance of Genome Resources)	Chr23			NP_571703 (RefSeq) NM_131628 (RefSeq)
	scn8ab	ZDB-GENE-060906-2 (Zebrafish Model Organism Database) 793996 (Entrez Gene) scn8ab (Alliance of Genome Resources)	Chr6			NP_001038648 (RefSeq) NM_001045183 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.