Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	HLA-DRB1	HGNC:4948 (HGNC) 3123 (Entrez Gene) 142857 (OMIM) HLA-DRB1 (Alliance of Genome Resources)	Chr6 p21.32	Chr6:32577902-32589848 (-) GRCh38	abdominal aortic aneurysm acute disseminated encephalomyelitis Addison's disease allergic asthma allergic bronchopulmonary aspergillosis allergic disease Alport syndrome alveolar echinococcosis Alzheimer's disease ankylosing spondylitis anti-basement membrane glomerulonephritis antiphospholipid syndrome aspirin-induced respiratory disease asthma atrophic gastritis autistic disorder autoimmune disease autoimmune hepatitis autoimmune polyendocrine syndrome autoimmune polyendocrine syndrome type 2 autoimmune thrombocytopenic purpura autoimmune thyroiditis bacterial infectious disease Behcet's disease breast cancer breast carcinoma celiac disease cerebral infarction cervix uteri carcinoma in situ Chagas disease choreatic disease cicatricial pemphigoid cystic echinococcosis diabetic angiopathy diabetic retinopathy endometriosis glaucoma Graves' disease Hantavirus hemorrhagic fever with renal syndrome hepatitis C human immunodeficiency virus infectious disease Human papillomavirus infectious disease hypothyroidism idiopathic pulmonary fibrosis infectious mononucleosis juvenile rheumatoid arthritis latex allergy leprosy liver cirrhosis lupus nephritis Meniere's disease mixed connective tissue disease multidrug-resistant tuberculosis multiple sclerosis myasthenia gravis myositis narcolepsy neuromyelitis optica optic neuritis paracoccidioidomycosis Parkinson's disease pemphigus peptic ulcer disease polyneuropathy primary progressive multiple sclerosis prostate cancer pulmonary sarcoidosis pulmonary tuberculosis pure red-cell aplasia renal cell carcinoma retinopathy of prematurity rheumatic fever rheumatic heart disease rheumatoid arthritis sarcoidosis schistosomiasis sensorineural hearing loss severe acute respiratory syndrome Sjogren's syndrome sympathetic ophthalmia systemic lupus erythematosus Takayasu's arteritis temporal arteritis thromboangiitis obliterans tuberculosis type 1 diabetes mellitus typhoid fever urticaria uveitis uveoparotid fever vitiligo Vogt-Koyanagi-Harada disease vulva cancer	P01911 (UniProt | EBI) NM_001359194 (RefSeq)
	HLA-DRB3	HGNC:4951 (HGNC) 3125 (Entrez Gene) 612735 (OMIM) HLA-DRB3 (Alliance of Genome Resources)	Chr6 p21.3		aspirin-induced respiratory disease asthma Graves' disease multiple sclerosis	P79483 (UniProt | EBI) NM_022555 (RefSeq)
	HLA-DRB4	HGNC:4952 (HGNC) 3126 (Entrez Gene) HLA-DRB4 (Alliance of Genome Resources)	Chr6 p21.3		aspirin-induced respiratory disease	P13762 (UniProt | EBI) NM_021983 (RefSeq)
	HLA-DRB5	HGNC:4953 (HGNC) 3127 (Entrez Gene) 604776 (OMIM) HLA-DRB5 (Alliance of Genome Resources)	Chr6 p21.32	Chr6:32517353-32530287 (-) GRCh38	acute disseminated encephalomyelitis Hantavirus hemorrhagic fever with renal syndrome	Q30154 (UniProt | EBI) NM_002125 (RefSeq)
mouse	H2-Eb1	MGI:95901 (MGI) 14969 (Entrez Gene) Gene Tree H2-Eb1 (Alliance of Genome Resources)	Chr17 17.98 cM	Chr17:34524841-34535648 (+) GRCm39		14969 (NCBI Gene Model) P18469 (UniProt | EBI) NM_010382 (RefSeq)
rat	RT1-Db1	RGD:1593282 (Rat Genome Database) 294270 (Entrez Gene) RT1-Db1 (Alliance of Genome Resources)	Chr20 p12			P18211 (UniProt | EBI) NM_001008884 (RefSeq)
zebrafish	mhc2bl	ZDB-GENE-030616-99 (Zebrafish Model Organism Database) 368703 (Entrez Gene) mhc2bl (Alliance of Genome Resources)	Chr8			XP_005167291 (RefSeq)
	mhc2d4b	ZDB-GENE-030131-4747 (Zebrafish Model Organism Database) 326022 (Entrez Gene) mhc2d4b (Alliance of Genome Resources)	Chr4			XP_005168179 (RefSeq)
	mhc2d8.35b2	ZDB-GENE-030616-171 (Zebrafish Model Organism Database) 563286 (Entrez Gene) mhc2d8.35b2 (Alliance of Genome Resources)	Chr8			NP_001074102 (RefSeq) NM_001080633 (RefSeq)
	mhc2d8.37b2	ZDB-GENE-091204-413 (Zebrafish Model Organism Database) 100332219 (Entrez Gene) mhc2d8.37b2 (Alliance of Genome Resources)	Chr8			XP_009302413 (RefSeq)
	mhc2dab	ZDB-GENE-980526-200 (Zebrafish Model Organism Database) 30762 (Entrez Gene) mhc2dab (Alliance of Genome Resources)	Chr8			NP_571551 (RefSeq) NM_131476 (RefSeq)
	mhc2dgb	ZDB-GENE-030616-319 (Zebrafish Model Organism Database) 368615 (Entrez Gene) mhc2dgb (Alliance of Genome Resources)	Chr8			NP_001007207 (RefSeq) NM_001007206 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.