Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	CXCR4	HGNC:2561 (HGNC) 7852 (Entrez Gene) 162643 (OMIM) CXCR4 (Alliance of Genome Resources)	Chr2 q22.1	Chr2:136114349-136119177 (-) GRCh38	acute myeloid leukemia leukopenia lymphoplasmacytic lymphoma osteoporosis osteosarcoma pancreatic adenocarcinoma prostate cancer stomach cancer T-cell acute lymphoblastic leukemia WHIM syndrome 1	P61073 (UniProt | EBI) NM_001348059 (RefSeq)
mouse	Cxcr4	MGI:109563 (MGI) 12767 (Entrez Gene) Gene Tree Cxcr4 (Alliance of Genome Resources)	Chr1 56.43 cM	Chr1:128515936-128520030 (-) GRCm39	cardiomyopathy congestive heart failure WHIM syndrome 1	ENSMUSG00000045382 (Ensembl Gene Model) ENSMUSP00000053489 (Ensembl) ENSMUST00000052172 (Ensembl)
rat	Cxcr4	RGD:620465 (Rat Genome Database) 60628 (Entrez Gene) Cxcr4 (Alliance of Genome Resources)	Chr13 q13			O08565 (UniProt | EBI) NM_022205 (RefSeq)
zebrafish	cxcr4a	ZDB-GENE-020102-1 (Zebrafish Model Organism Database) 140747 (Entrez Gene) cxcr4a (Alliance of Genome Resources)	Chr6			NP_571957 (RefSeq) NM_131882 (RefSeq)
	cxcr4b	ZDB-GENE-010614-1 (Zebrafish Model Organism Database) 114447 (Entrez Gene) cxcr4b (Alliance of Genome Resources)	Chr9			NP_571909 (RefSeq) NM_131834 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.