Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	APOE	HGNC:613 (HGNC) 348 (Entrez Gene) 107741 (OMIM) APOE (Alliance of Genome Resources)	Chr19 q13.32	Chr19:44905791-44909393 (+) GRCh38	abdominal aortic aneurysm age related macular degeneration 1 Alzheimer's disease Alzheimer's disease 2 Alzheimer's disease 3 amyotrophic lateral sclerosis angle-closure glaucoma atherosclerosis atopic dermatitis bile duct cancer breast cancer cerebral infarction cerebrovascular disease cholelithiasis congestive heart failure coronary artery disease diabetes mellitus diabetic retinopathy dilated cardiomyopathy exfoliation syndrome familial combined hyperlipidemia gallbladder cancer herpes simplex herpes simplex virus keratitis hyperlipoproteinemia type III hyperuricemia Kuhnt-Junius degeneration low tension glaucoma lung carcinoma macular degeneration malaria multiple myeloma myocardial infarction open-angle glaucoma primary open angle glaucoma psoriasis retinal disease sea-blue histiocytosis sensorineural hearing loss Sjogren's syndrome	P02649 (UniProt | EBI) NM_001302690 (RefSeq)
mouse	Apoe	MGI:88057 (MGI) 11816 (Entrez Gene) Gene Tree Apoe (Alliance of Genome Resources)	Chr7 9.94 cM	Chr7:19430034-19433113 (-) GRCm39		ENSMUSG00000002985 (Ensembl Gene Model) ENSMUSP00000133302 (Ensembl) ENSMUST00000174064 (Ensembl)
rat	Apoe	RGD:2138 (Rat Genome Database) 25728 (Entrez Gene) Apoe (Alliance of Genome Resources)	Chr1 q21			P02650 (UniProt | EBI) NM_001270682 (RefSeq)
zebrafish	apoea	ZDB-GENE-010724-18 (Zebrafish Model Organism Database) 553587 (Entrez Gene) apoea (Alliance of Genome Resources)	Chr19			NP_001018401 (RefSeq) NM_001020565 (RefSeq)
	apoeb	ZDB-GENE-980526-368 (Zebrafish Model Organism Database) 30314 (Entrez Gene) apoeb (Alliance of Genome Resources)	Chr16			O42364 (UniProt | EBI) NM_131098 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.