Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	PKLR	HGNC:9020 (HGNC) 5313 (Entrez Gene) 609712 (OMIM) PKLR (Alliance of Genome Resources)	Chr1 q22	Chr1:155289293-155308654 (-) GRCh38	congenital nonspherocytic hemolytic anemia Gaucher's disease malaria pyruvate kinase deficiency of red cells type 2 diabetes mellitus	P30613 (UniProt | EBI) NM_181871 (RefSeq)
mouse	Pklr	MGI:97604 (MGI) 18770 (Entrez Gene) Gene Tree Pklr (Alliance of Genome Resources)	Chr3 39.01 cM	Chr3:89043449-89054091 (+) GRCm39	malaria pyruvate kinase deficiency of red cells	ENSMUSG00000041237 (Ensembl Gene Model) ENSMUSP00000035417 (Ensembl) ENSMUST00000047111 (Ensembl)
rat	Pklr	RGD:3336 (Rat Genome Database) 24651 (Entrez Gene) Pklr (Alliance of Genome Resources)	Chr2 q34			P12928 (UniProt | EBI) NM_012624 (RefSeq)
zebrafish	pklr	ZDB-GENE-010907-1 (Zebrafish Model Organism Database) 114551 (Entrez Gene) pklr (Alliance of Genome Resources)	Chr16			NP_958446 (RefSeq) NM_201289 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.