Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	LMNA	HGNC:6636 (HGNC) 4000 (Entrez Gene) 150330 (OMIM) LMNA (Alliance of Genome Resources)	Chr1 q22	Chr1:156082572-156140081 (+) GRCh38	arrhythmogenic right ventricular cardiomyopathy atrioventricular block autosomal dominant Emery-Dreifuss muscular dystrophy 2 autosomal recessive Emery-Dreifuss muscular dystrophy 3 cerebrovascular disease Charcot-Marie-Tooth disease type 2B1 congenital muscular dystrophy due to LMNA mutation dilated cardiomyopathy dilated cardiomyopathy 1A dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome Emery-Dreifuss muscular dystrophy familial partial lipodystrophy familial partial lipodystrophy type 2 lipoatrophic diabetes mellitus lipodystrophy mandibuloacral dysplasia type A lipodystrophy progeria restrictive dermopathy 2 type 2 diabetes mellitus Werner syndrome	P02545 (UniProt | EBI) NM_001257374 (RefSeq)
mouse	Lmna	MGI:96794 (MGI) 16905 (Entrez Gene) Gene Tree Lmna (Alliance of Genome Resources)	Chr3 38.84 cM	Chr3:88388455-88413842 (-) GRCm39	achalasia Charcot-Marie-Tooth disease type 2B1 congenital muscular dystrophy due to LMNA mutation dilated cardiomyopathy 1A Emery-Dreifuss muscular dystrophy otitis media progeria	16905 (NCBI Gene Model) P48678 (UniProt | EBI) NM_001002011 (RefSeq)
rat	Lmna	RGD:620456 (Rat Genome Database) 60374 (Entrez Gene) Lmna (Alliance of Genome Resources)	Chr2 q34			P48679 (UniProt | EBI) NM_021755 (RefSeq)
zebrafish	lmna	ZDB-GENE-020424-3 (Zebrafish Model Organism Database) 195815 (Entrez Gene) lmna (Alliance of Genome Resources)	Chr16			NP_694503 (RefSeq) NM_152971 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.