Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	MTHFD1	HGNC:7432 (HGNC) 4522 (Entrez Gene) 172460 (OMIM) MTHFD1 (Alliance of Genome Resources)	Chr14 q23.3	Chr14:64388031-64463457 (+) GRCh38	abdominal aortic aneurysm cleft lip cleft palate developmental cardiac valvular defect Down syndrome neural tube defect spina bifida tetralogy of Fallot	P11586 (UniProt | EBI) NM_001364837 (RefSeq)
mouse	Mthfd1	MGI:1342005 (MGI) 108156 (Entrez Gene) Gene Tree Mthfd1 (Alliance of Genome Resources)	Chr12 33.52 cM	Chr12:76302072-76366577 (+) GRCm39		ENSMUSG00000021048 (Ensembl Gene Model) ENSMUSP00000021443 (Ensembl) ENSMUST00000021443 (Ensembl)
rat	Mthfd1	RGD:708531 (Rat Genome Database) 64300 (Entrez Gene) Mthfd1 (Alliance of Genome Resources)	Chr6 q24			P27653 (UniProt | EBI) NM_022508 (RefSeq)
	Mthfd1-ps1	RGD:1591768 (Rat Genome Database) 680432 (Entrez Gene) Mthfd1-ps1 (Alliance of Genome Resources)	Chr3 q36			XP_063141058 (RefSeq)
zebrafish	mthfd1a	ZDB-GENE-041001-127 (Zebrafish Model Organism Database) 567587 (Entrez Gene) mthfd1a (Alliance of Genome Resources)	Chr20			XP_068071749 (RefSeq)
	mthfd1b	ZDB-GENE-020905-4 (Zebrafish Model Organism Database) 260441 (Entrez Gene) mthfd1b (Alliance of Genome Resources)	Chr17			NP_955823 (RefSeq) NM_199529 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.