Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SERPINA1	HGNC:8941 (HGNC) 5265 (Entrez Gene) 107400 (OMIM) SERPINA1 (Alliance of Genome Resources)	Chr14 q32.13	Chr14:94376747-94390693 (-) GRCh38	alpha 1-antitrypsin deficiency arteriosclerosis chemical colitis chronic obstructive pulmonary disease human immunodeficiency virus infectious disease ileitis liver cirrhosis liver disease pulmonary emphysema	P01009 (UniProt | EBI) NM_000295 (RefSeq)
mouse	Serpina1a	MGI:891971 (MGI) 20700 (Entrez Gene) Gene Tree Serpina1a (Alliance of Genome Resources)	Chr12 52.98 cM	Chr12:103819848-103829821 (-) GRCm39		ENSMUSG00000066366 (Ensembl Gene Model) ENSMUSP00000072652 (Ensembl) ENSMUST00000072876 (Ensembl)
rat	Serpina1	RGD:3326 (Rat Genome Database) 24648 (Entrez Gene) Serpina1 (Alliance of Genome Resources)	Chr6 q32			P17475 (UniProt | EBI) NM_001434341 (RefSeq)
zebrafish	serpina1	ZDB-GENE-030131-1421 (Zebrafish Model Organism Database) 322701 (Entrez Gene) serpina1 (Alliance of Genome Resources)	Chr20			NP_001071226 (RefSeq) NM_001077758 (RefSeq)
	serpina1l	ZDB-GENE-040721-3 (Zebrafish Model Organism Database) 321195 (Entrez Gene) serpina1l (Alliance of Genome Resources)	Chr20			NP_001013277 (RefSeq) NM_001013259 (RefSeq)
	serpina7	ZDB-GENE-041010-47 (Zebrafish Model Organism Database) 564060 (Entrez Gene) serpina7 (Alliance of Genome Resources)	Chr5			NP_001099059 (RefSeq) NM_001105589 (RefSeq)
	si:ch211-186e20.7	ZDB-GENE-110407-6 (Zebrafish Model Organism Database) 566630 (Entrez Gene) si:ch211-186e20.7 (Alliance of Genome Resources)	Chr5			XP_021329695 (RefSeq)
	zgc:113828	ZDB-GENE-050913-23 (Zebrafish Model Organism Database) 556938 (Entrez Gene) zgc:113828 (Alliance of Genome Resources)	Chr5			NP_001025278 (RefSeq) NM_001030107 (RefSeq)
	zgc:174259	ZDB-GENE-080213-10 (Zebrafish Model Organism Database) 791587 (Entrez Gene) zgc:174259 (Alliance of Genome Resources)	Chr5			NP_001104678 (RefSeq) NM_001111208 (RefSeq)
	zgc:174260	ZDB-GENE-080213-9 (Zebrafish Model Organism Database) 100137107 (Entrez Gene) zgc:174260 (Alliance of Genome Resources)	Chr5			NP_001108176 (RefSeq) NM_001114704 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.