Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	C4A	HGNC:1323 (HGNC) 720 (Entrez Gene) 120810 (OMIM) C4A (Alliance of Genome Resources)	Chr6 p21.33	Chr6:31982057-32002681 (+) GRCh38	complement component 4a deficiency Graves' disease renal cell carcinoma systemic lupus erythematosus vitiligo	P0C0L4 (UniProt | EBI) NM_007293 (RefSeq)
	C4B	HGNC:1324 (HGNC) 721 (Entrez Gene) 120820 (OMIM) C4B (Alliance of Genome Resources)	Chr6 p21.33	Chr6:32014795-32035418 (+) GRCh38	autistic disorder complement component 4b deficiency Graves' disease renal cell carcinoma rheumatoid arthritis systemic lupus erythematosus	P0C0L5 (UniProt | EBI) NM_001002029 (RefSeq)
	C4B_2	HGNC:42398 (HGNC) 100293534 (Entrez Gene) C4B_2 (Alliance of Genome Resources)	Chr6			NP_001229752 (RefSeq) NM_001242823 (RefSeq)
mouse	C4b	MGI:88228 (MGI) 12268 (Entrez Gene) Gene Tree C4b (Alliance of Genome Resources)	Chr17 18.29 cM	Chr17:34947354-34962856 (-) GRCm39	systemic lupus erythematosus	ENSMUSG00000073418 (Ensembl Gene Model) ENSMUSP00000069418 (Ensembl) ENSMUST00000069507 (Ensembl)
rat	C4a	RGD:620005 (Rat Genome Database) 24233 (Entrez Gene) C4a (Alliance of Genome Resources)	Chr20 p12			P08649 (UniProt | EBI) NM_031504 (RefSeq)
	C4b	RGD:1591983 (Rat Genome Database) 406161 (Entrez Gene) C4b (Alliance of Genome Resources)	Chr20 p12			NP_001002805 (RefSeq) NM_001002805 (RefSeq)
zebrafish	c4	ZDB-GENE-030131-5697 (Zebrafish Model Organism Database) 566261 (Entrez Gene) c4 (Alliance of Genome Resources)	Chr15			XP_005157429 (RefSeq)
	c4b	ZDB-GENE-100805-2 (Zebrafish Model Organism Database) 794635 (Entrez Gene) c4b (Alliance of Genome Resources)	Chr16			NP_001352066 (RefSeq) NM_001365137 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.