Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	OPTN	HGNC:17142 (HGNC) 10133 (Entrez Gene) 602432 (OMIM) OPTN (Alliance of Genome Resources)	Chr10 p13	Chr10:13099449-13138308 (+) GRCh38	amyotrophic lateral sclerosis amyotrophic lateral sclerosis type 12 glaucoma low tension glaucoma open-angle glaucoma Paget's disease of bone primary open angle glaucoma	Q96CV9 (UniProt | EBI) NM_001008212 (RefSeq)
mouse	Optn	MGI:1918898 (MGI) 71648 (Entrez Gene) Gene Tree Optn (Alliance of Genome Resources)	Chr2 3.15 cM	Chr2:5025453-5068862 (-) GRCm39	low tension glaucoma	ENSMUSG00000026672 (Ensembl Gene Model) ENSMUSP00000110648 (Ensembl) ENSMUST00000114996 (Ensembl)
rat	Optn	RGD:628886 (Rat Genome Database) 246294 (Entrez Gene) Optn (Alliance of Genome Resources)	Chr17 q12.3			Q8R5M4 (UniProt | EBI) NM_145081 (RefSeq)
zebrafish	optn	ZDB-GENE-030131-8103 (Zebrafish Model Organism Database) 336159 (Entrez Gene) optn (Alliance of Genome Resources)	Chr4			Q5RI56 (UniProt | EBI) NM_001100066 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.