HFE Vertebrate HGNC

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Vertebrate Homology

Source

Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
- human
- mouse
- rat
- zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences select all deselect all Go
human	HFE	HGNC:4886 (HGNC) 3077 (Entrez Gene) 613609 (OMIM) HFE (Alliance of Genome Resources)	Chr6 p22.2	Chr6:26087226-26098343 (+) GRCh38	acute lymphoblastic leukemia Alzheimer's disease aphthous stomatitis beta thalassemia breast cancer cardiomyopathy colorectal cancer Crohn's disease cystic fibrosis diabetes mellitus diabetic retinopathy dilated cardiomyopathy hemochromatosis hemochromatosis type 1 hepatic veno-occlusive disease hepatocellular carcinoma intestinal obstruction iron deficiency anemia juvenile rheumatoid arthritis liver cirrhosis liver disease metabolic dysfunction-associated steatotic liver disease multiple myeloma myelodysplastic syndrome myelofibrosis myocardial infarction obesity osteoarthritis ovarian cancer polycythemia vera polymyalgia rheumatica porphyria cutanea tarda rheumatoid arthritis type 2 diabetes mellitus	Q30201 (UniProt \| EBI) NM_139008 (RefSeq)
mouse	Hfe	MGI:109191 (MGI) 15216 (Entrez Gene) Gene Tree Hfe (Alliance of Genome Resources)	Chr13 9.88 cM	Chr13:23886017-23894837 (-) GRCm39	hemochromatosis type 1	15216 (NCBI Gene Model) P70387 (UniProt \| EBI) NM_010424 (RefSeq)
rat	Hfe	RGD:2793 (Rat Genome Database) 29199 (Entrez Gene) Hfe (Alliance of Genome Resources)	Chr17 p11			O35799 (UniProt \| EBI) NM_001173434 (RefSeq)
zebrafish	mhc1zaa	ZDB-GENE-030916-1 (Zebrafish Model Organism Database) 378479 (Entrez Gene) mhc1zaa (Alliance of Genome Resources)	Chr1			NP_919406 (RefSeq) NM_194425 (RefSeq)
	mhc1zba	ZDB-GENE-040426-2149 (Zebrafish Model Organism Database) 791453 (Entrez Gene) mhc1zba (Alliance of Genome Resources)	Chr1			NP_001103588 (RefSeq) NM_001110118 (RefSeq)
	mhc1zca	ZDB-GENE-070424-4 (Zebrafish Model Organism Database) 556341 (Entrez Gene) mhc1zca (Alliance of Genome Resources)	Chr1			NP_001077014 (RefSeq) NM_001083545 (RefSeq)
	mhc1zea	ZDB-GENE-070705-176 (Zebrafish Model Organism Database) 565708 (Entrez Gene) mhc1zea (Alliance of Genome Resources)	Chr1			NP_001083019 (RefSeq) NM_001089550 (RefSeq)
	mhc1zfa	ZDB-GENE-130206-9 (Zebrafish Model Organism Database) 102467220 (Entrez Gene) mhc1zfa (Alliance of Genome Resources)	Chr3			NP_001274027 (RefSeq) NM_001287098 (RefSeq)
	mhc1zja	ZDB-GENE-130206-11 (Zebrafish Model Organism Database) 571647 (Entrez Gene) mhc1zja (Alliance of Genome Resources)	Chr3			NP_001103188 (RefSeq) NM_001109718 (RefSeq)
	mhc1zka	ZDB-GENE-130206-5 (Zebrafish Model Organism Database) 100536229 (Entrez Gene) mhc1zka (Alliance of Genome Resources)	ChrUN			NP_001289174 (RefSeq) NM_001302245 (RefSeq)