Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	HLA-A	HGNC:4931 (HGNC) 3105 (Entrez Gene) 142800 (OMIM) HLA-A (Alliance of Genome Resources)	Chr6 p22.1	Chr6:29941260-29949572 (+) GRCh38	acquired immunodeficiency syndrome central nervous system vasculitis cerebral infarction Moyamoya disease pre-eclampsia scleroderma Stevens-Johnson syndrome Takayasu's arteritis thromboangiitis obliterans tuberculosis uveitis vulva cancer	P04439 (UniProt | EBI) NM_002116 (RefSeq)
	HLA-B	HGNC:4932 (HGNC) 3106 (Entrez Gene) 142830 (OMIM) HLA-B (Alliance of Genome Resources)	Chr6 p21.33	Chr6:31353872-31367067 (-) GRCh38	acute retinal necrosis syndrome allergic asthma alopecia ankylosing spondylitis anterior uveitis asthma Behcet's disease birdshot chorioretinopathy cerebral infarction cervical cancer colitis COVID-19 Cytomegalovirus retinitis dermatitis diabetic retinopathy erythema nodosum Graves' disease human immunodeficiency virus infectious disease Meniere's disease mitral valve prolapse occupational asthma otosclerosis reactive arthritis retinal vasculitis retinopathy of prematurity sarcoidosis sensorineural hearing loss severe acute respiratory syndrome spondyloarthropathy Stevens-Johnson syndrome synovitis Takayasu's arteritis thrombophlebitis trachoma tuberculosis uveitis	P01889 (UniProt | EBI) NM_005514 (RefSeq)
	HLA-C	HGNC:4933 (HGNC) 3107 (Entrez Gene) 142840 (OMIM) HLA-C (Alliance of Genome Resources)	Chr6 p21.33	Chr6:31268749-31272130 (-) GRCh38	allergic asthma COVID-19 human immunodeficiency virus infectious disease psoriasis 1	P10321 (UniProt | EBI) NM_001243042 (RefSeq)
	HLA-E	HGNC:4962 (HGNC) 3133 (Entrez Gene) 143010 (OMIM) HLA-E (Alliance of Genome Resources)	Chr6 p22.1	Chr6:30489509-30494194 (+) GRCh38	occupational asthma	P13747 (UniProt | EBI) NM_005516 (RefSeq)
mouse	H2-Q4	MGI:95933 (MGI) 15015 (Entrez Gene) Gene Tree H2-Q4 (Alliance of Genome Resources)	Chr17 18.65 cM	Chr17:35598593-35603650 (+) GRCm39		15015 (NCBI Gene Model) NP_001137161 (RefSeq) NM_001143689 (RefSeq)
rat	RT1-A1	RGD:1595924 (Rat Genome Database) 24973 (Entrez Gene) RT1-A1 (Alliance of Genome Resources)	Chr20 p12			NP_001008827 (RefSeq) NM_001008827 (RefSeq)
	RT1-A2	RGD:1595923 (Rat Genome Database) 24974 (Entrez Gene) RT1-A2 (Alliance of Genome Resources)	Chr20 p12			NP_001008829 (RefSeq) NM_001008829 (RefSeq)
	RT1-CE2	RGD:1598235 (Rat Genome Database) 414779 (Entrez Gene) RT1-CE2 (Alliance of Genome Resources)	Chr20 p12			NP_001008840 (RefSeq) NM_001008840 (RefSeq)
	RT1-CE5	RGD:1595868 (Rat Genome Database) 309607 (Entrez Gene) RT1-CE5 (Alliance of Genome Resources)	Chr20 p12			NP_001029158 (RefSeq) NM_001008843 (RefSeq)
	RT1-CE7	RGD:1595786 (Rat Genome Database) 368153 (Entrez Gene) RT1-CE7 (Alliance of Genome Resources)	Chr20 p12			NP_001008845 (RefSeq) NM_001008845 (RefSeq)
	RT1-CE10	RGD:1359292 (Rat Genome Database) 414792 (Entrez Gene) RT1-CE10 (Alliance of Genome Resources)	Chr20 p12			NP_001008833 (RefSeq) NM_001008833 (RefSeq)
	RT1-CE15	RGD:1359630 (Rat Genome Database) 414789 (Entrez Gene) RT1-CE15 (Alliance of Genome Resources)	Chr20			NP_001008838 (RefSeq) NM_001008838 (RefSeq)
zebrafish	mhc1lja	ZDB-GENE-140820-11 (Zebrafish Model Organism Database) 100150018 (Entrez Gene) mhc1lja (Alliance of Genome Resources)	Chr25			NP_001314847 (RefSeq) NM_001327918 (RefSeq)
	mhc1zaa	ZDB-GENE-030916-1 (Zebrafish Model Organism Database) 378479 (Entrez Gene) mhc1zaa (Alliance of Genome Resources)	Chr1			NP_919406 (RefSeq) NM_194425 (RefSeq)
	mhc1zba	ZDB-GENE-040426-2149 (Zebrafish Model Organism Database) 791453 (Entrez Gene) mhc1zba (Alliance of Genome Resources)	Chr1			NP_001103588 (RefSeq) NM_001110118 (RefSeq)
	mhc1zca	ZDB-GENE-070424-4 (Zebrafish Model Organism Database) 556341 (Entrez Gene) mhc1zca (Alliance of Genome Resources)	Chr1			NP_001077014 (RefSeq) NM_001083545 (RefSeq)
	mhc1zea	ZDB-GENE-070705-176 (Zebrafish Model Organism Database) 565708 (Entrez Gene) mhc1zea (Alliance of Genome Resources)	Chr1			NP_001083019 (RefSeq) NM_001089550 (RefSeq)
	mhc1zfa	ZDB-GENE-130206-9 (Zebrafish Model Organism Database) 102467220 (Entrez Gene) mhc1zfa (Alliance of Genome Resources)	Chr3			NP_001274027 (RefSeq) NM_001287098 (RefSeq)
	mhc1zja	ZDB-GENE-130206-11 (Zebrafish Model Organism Database) 571647 (Entrez Gene) mhc1zja (Alliance of Genome Resources)	Chr3			NP_001103188 (RefSeq) NM_001109718 (RefSeq)
	mhc1zka	ZDB-GENE-130206-5 (Zebrafish Model Organism Database) 100536229 (Entrez Gene) mhc1zka (Alliance of Genome Resources)	ChrUN			NP_001289174 (RefSeq) NM_001302245 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.