Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	TLR4	HGNC:11850 (HGNC) 7099 (Entrez Gene) 603030 (OMIM) TLR4 (Alliance of Genome Resources)	Chr9 q33.1	Chr9:117704175-117724735 (+) GRCh38	allergic contact dermatitis allergic rhinitis Alzheimer's disease anterior uveitis arteriosclerosis arthritis asthma atopic dermatitis Behcet's disease breast cancer carotid artery disease chronic obstructive pulmonary disease coronary artery disease diabetes mellitus diabetic neuropathy diabetic retinopathy exfoliation syndrome familial Mediterranean fever hepatocellular carcinoma invasive aspergillosis keratitis low tension glaucoma macular degeneration melanoma meningococcal meningitis myocardial infarction primary open angle glaucoma pulmonary tuberculosis respiratory allergy respiratory syncytial virus infectious disease temporal arteritis tympanosclerosis type 2 diabetes mellitus urinary tract infection vitiligo	O00206 (UniProt | EBI) NM_138554 (RefSeq)
mouse	Tlr4	MGI:96824 (MGI) 21898 (Entrez Gene) Gene Tree Tlr4 (Alliance of Genome Resources)	Chr4 34.66 cM	Chr4:66745788-66765338 (+) GRCm39	pulmonary emphysema	21898 (NCBI Gene Model) Q9QUK6 (UniProt | EBI) NM_021297 (RefSeq)
rat	Tlr4	RGD:3870 (Rat Genome Database) 29260 (Entrez Gene) Tlr4 (Alliance of Genome Resources)	Chr5 q24			Q9QX05 (UniProt | EBI) NM_019178 (RefSeq)
zebrafish	tlr4al	ZDB-GENE-090507-2 (Zebrafish Model Organism Database) 795671 (Entrez Gene) tlr4al (Alliance of Genome Resources)	Chr13			NP_001315534 (RefSeq) NM_001328605 (RefSeq)
	tlr4ba	ZDB-GENE-040219-8 (Zebrafish Model Organism Database) 403131 (Entrez Gene) tlr4ba (Alliance of Genome Resources)	Chr13			NP_001124523 (RefSeq) NM_001131051 (RefSeq)
	tlr4bb	ZDB-GENE-040219-9 (Zebrafish Model Organism Database) 403132 (Entrez Gene) tlr4bb (Alliance of Genome Resources)	Chr13			NP_997978 (RefSeq) NM_212813 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.