Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	MLH1	HGNC:7127 (HGNC) 4292 (Entrez Gene) 120436 (OMIM) MLH1 (Alliance of Genome Resources)	Chr3 p22.2	Chr3:36993226-37050896 (+) GRCh38	colorectal cancer esophagus squamous cell carcinoma hereditary nonpolyposis colorectal cancer type 2 lung cancer Lynch syndrome mismatch repair cancer syndrome Muir-Torre syndrome sporadic breast cancer	P40692 (UniProt | EBI) NM_001354616 (RefSeq)
mouse	Mlh1	MGI:101938 (MGI) 17350 (Entrez Gene) Gene Tree Mlh1 (Alliance of Genome Resources)	Chr9 60.92 cM	Chr9:111057296-111100854 (-) GRCm39	Lynch syndrome	17350 (NCBI Gene Model) Q9JK91 (UniProt | EBI) NM_026810 (RefSeq)
rat	Mlh1	RGD:620937 (Rat Genome Database) 81685 (Entrez Gene) Mlh1 (Alliance of Genome Resources)	Chr8 q32			P97679 (UniProt | EBI) NM_031053 (RefSeq)
zebrafish	mlh1	ZDB-GENE-040426-1600 (Zebrafish Model Organism Database) 393632 (Entrez Gene) mlh1 (Alliance of Genome Resources)	Chr13			NP_956953 (RefSeq) NM_001431064 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.