Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	HMGCL	HGNC:5005 (HGNC) 3155 (Entrez Gene) 613898 (OMIM) HMGCL (Alliance of Genome Resources)	Chr1 p36.11	Chr1:23801885-23838620 (-) GRCh38	3-hydroxy-3-methylglutaryl-CoA lyase deficiency amino acid metabolic disorder	P35914 (UniProt | EBI) NM_001166059 (RefSeq)
mouse	Hmgcl	MGI:96158 (MGI) 15356 (Entrez Gene) Gene Tree Hmgcl (Alliance of Genome Resources)	Chr4 68.14 cM	Chr4:135673776-135689926 (+) GRCm39		15356 (NCBI Gene Model) P38060 (UniProt | EBI) NM_001357530 (RefSeq)
rat	Hmgcl	RGD:620554 (Rat Genome Database) 79238 (Entrez Gene) Hmgcl (Alliance of Genome Resources)	Chr5 q36			P97519 (UniProt | EBI) NM_024386 (RefSeq)
zebrafish	hmgcl	ZDB-GENE-040426-958 (Zebrafish Model Organism Database) 394190 (Entrez Gene) hmgcl (Alliance of Genome Resources)	Chr17			NP_957509 (RefSeq) NM_201215 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.