Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	ERCC2	HGNC:3434 (HGNC) 2068 (Entrez Gene) 126340 (OMIM) ERCC2 (Alliance of Genome Resources)	Chr19 q13.32	Chr19:45349837-45370918 (-) GRCh38	acoustic neuroma acquired immunodeficiency syndrome acute lymphoblastic leukemia acute myeloid leukemia autosomal recessive congenital ichthyosis breast cancer cerebrooculofacioskeletal syndrome 2 chronic myeloid leukemia coronary artery disease hepatocellular carcinoma high grade glioma lung non-small cell carcinoma macular degeneration melanoma multiple myeloma myelodysplastic syndrome oral mucosa leukoplakia ovary epithelial cancer pancreatic cancer photosensitive trichothiodystrophy 1 prostate cancer senile cataract skin disease stomach cancer urinary bladder cancer xeroderma pigmentosum xeroderma pigmentosum group D	P18074 (UniProt | EBI) NM_000400 (RefSeq)
mouse	Ercc2	MGI:95413 (MGI) 13871 (Entrez Gene) Gene Tree Ercc2 (Alliance of Genome Resources)	Chr7 9.62 cM	Chr7:19115942-19129619 (+) GRCm39	photosensitive trichothiodystrophy xeroderma pigmentosum group D	13871 (NCBI Gene Model) O08811 (UniProt | EBI) NM_007949 (RefSeq)
rat	Ercc2	RGD:1309109 (Rat Genome Database) 308415 (Entrez Gene) Ercc2 (Alliance of Genome Resources)	Chr1 q21			NP_001166280 (RefSeq) NM_001172809 (RefSeq)
zebrafish	ercc2	ZDB-GENE-040426-997 (Zebrafish Model Organism Database) 393900 (Entrez Gene) ercc2 (Alliance of Genome Resources)	Chr15			NP_957220 (RefSeq) NM_200926 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.