Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	KRAS	HGNC:6407 (HGNC) 3845 (Entrez Gene) 190070 (OMIM) KRAS (Alliance of Genome Resources)	Chr12 p12.1	Chr12:25205246-25250936 (-) GRCh38	acute lymphoblastic leukemia acute myeloid leukemia arteriovenous malformations of the brain autoimmune lymphoproliferative syndrome type 4 breast cancer cardiofaciocutaneous syndrome cardiofaciocutaneous syndrome 2 colorectal cancer endometrial hyperplasia intellectual disability intrahepatic cholangiocarcinoma Klatskin's tumor linear nevus sebaceous syndrome lung adenocarcinoma lung cancer Lynch syndrome malignant astrocytoma multiple myeloma myeloid sarcoma Noonan syndrome Noonan syndrome 3 oculoectodermal syndrome pancreatic cancer pancreatic mucinous cystadenoma seminoma stomach cancer stomach carcinoma urinary bladder cancer	P01116 (UniProt | EBI) NM_004985 (RefSeq)
mouse	Kras	MGI:96680 (MGI) 16653 (Entrez Gene) Gene Tree Kras (Alliance of Genome Resources)	Chr6 77.37 cM	Chr6:145162425-145195965 (-) GRCm39	arteriovenous malformations of the brain endometriosis intrahepatic cholangiocarcinoma juvenile myelomonocytic leukemia lung cancer Noonan syndrome 3 pancreatic carcinoma prostate cancer	ENSMUSG00000030265 (Ensembl Gene Model) ENSMUSP00000107339 (Ensembl) ENSMUST00000111710 (Ensembl)
rat	Kras	RGD:2981 (Rat Genome Database) 24525 (Entrez Gene) Kras (Alliance of Genome Resources)	Chr4 q44			P08644 (UniProt | EBI) NM_031515 (RefSeq)
zebrafish	kras	ZDB-GENE-040808-67 (Zebrafish Model Organism Database) 445289 (Entrez Gene) kras (Alliance of Genome Resources)	Chr25			NP_001003744 (RefSeq) NM_001003744 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.