Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	OPA1	HGNC:8140 (HGNC) 4976 (Entrez Gene) 605290 (OMIM) OPA1 (Alliance of Genome Resources)	Chr3 q29	Chr3:193593144-193697811 (+) GRCh38	Behr syndrome dominant optic atrophy plus syndrome mitochondrial DNA depletion syndrome 14 optic atrophy optic atrophy 1	O60313 (UniProt | EBI) NM_130831 (RefSeq)
mouse	Opa1	MGI:1921393 (MGI) 74143 (Entrez Gene) Gene Tree Opa1 (Alliance of Genome Resources)	Chr16 20.65 cM	Chr16:29398152-29473702 (+) GRCm39	optic atrophy	ENSMUSG00000038084 (Ensembl Gene Model) ENSMUSP00000123880 (Ensembl) ENSMUST00000161186 (Ensembl)
rat	Opa1	RGD:708423 (Rat Genome Database) 171116 (Entrez Gene) Opa1 (Alliance of Genome Resources)	Chr11 q22			Q2TA68 (UniProt | EBI) NM_001433908 (RefSeq)
zebrafish	opa1	ZDB-GENE-041114-7 (Zebrafish Model Organism Database) 492332 (Entrez Gene) opa1 (Alliance of Genome Resources)	Chr6			Q5U3A7 (UniProt | EBI) NM_001007298 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.