Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SHANK3	HGNC:14294 (HGNC) 85358 (Entrez Gene) 606230 (OMIM) SHANK3 (Alliance of Genome Resources)	Chr22 q13.33	Chr22:50672823-50733212 (+) GRCh38	Phelan-McDermid syndrome schizophrenia 15	Q9BYB0 (UniProt | EBI) NM_001080420 (RefSeq)
mouse	Shank3	MGI:1930016 (MGI) 58234 (Entrez Gene) Gene Tree Shank3 (Alliance of Genome Resources)	Chr15 44.96 cM	Chr15:89383826-89444464 (+) GRCm39	autism spectrum disorder Phelan-McDermid syndrome schizophrenia	ENSMUSG00000022623 (Ensembl Gene Model) ENSMUSP00000104932 (Ensembl) ENSMUST00000109309 (Ensembl)
rat	Shank3	RGD:69264 (Rat Genome Database) 59312 (Entrez Gene) Shank3 (Alliance of Genome Resources)	Chr7 q34			Q9JLU4 (UniProt | EBI) NM_021676 (RefSeq)
zebrafish	shank3a	ZDB-GENE-060503-369 (Zebrafish Model Organism Database) 557701 (Entrez Gene) shank3a (Alliance of Genome Resources)	Chr18			XP_021330057 (RefSeq)
	shank3b	ZDB-GENE-041210-74 (Zebrafish Model Organism Database) 566152 (Entrez Gene) shank3b (Alliance of Genome Resources)	Chr4			XP_068074271 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.