Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	FAS	HGNC:11920 (HGNC) 355 (Entrez Gene) 134637 (OMIM) FAS (Alliance of Genome Resources)	Chr10 q23.31	Chr10:88953813-89029605 (+) GRCh38	acute myeloid leukemia adult T-cell leukemia/lymphoma Alzheimer's disease autoimmune lymphoproliferative syndrome breast cancer chronic myeloid leukemia cystic fibrosis HELLP syndrome human immunodeficiency virus infectious disease lymphoproliferative syndrome melanoma multiple sclerosis nasal type extranodal NK/T-cell lymphoma pre-eclampsia prostate cancer relapsing-remitting multiple sclerosis renal cell carcinoma rheumatoid arthritis systemic lupus erythematosus urinary bladder cancer	P25445 (UniProt | EBI) NM_152872 (RefSeq)
mouse	Fas	MGI:95484 (MGI) 14102 (Entrez Gene) Gene Tree Fas (Alliance of Genome Resources)	Chr19 29.48 cM	Chr19:34268066-34305172 (+) GRCm39	autoimmune lymphoproliferative syndrome Sjogren's syndrome systemic lupus erythematosus	ENSMUSG00000024778 (Ensembl Gene Model) ENSMUSP00000025691 (Ensembl) ENSMUST00000025691 (Ensembl)
rat	Fas	RGD:619831 (Rat Genome Database) 246097 (Entrez Gene) Fas (Alliance of Genome Resources)	Chr1 q52			Q63199 (UniProt | EBI) NM_139194 (RefSeq)
zebrafish	fas	ZDB-GENE-061019-2 (Zebrafish Model Organism Database) 768248 (Entrez Gene) fas (Alliance of Genome Resources)	Chr17			XP_690447 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.