Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	ERCC6	HGNC:3438 (HGNC) 2074 (Entrez Gene) 609413 (OMIM) ERCC6 (Alliance of Genome Resources)	Chr10 q11.23	Chr10:49434881-49539538 (-) GRCh38	age related macular degeneration 5 cerebrooculofacioskeletal syndrome 1 Cockayne syndrome Cockayne syndrome B colorectal cancer colorectal carcinoma De Sanctis-Cacchione syndrome larynx cancer lung cancer lung non-small cell carcinoma polyneuropathy due to drug primary ovarian insufficiency 11 stomach cancer UV-sensitive syndrome	Q03468 (UniProt | EBI) NM_001277059 (RefSeq)
mouse	Ercc6	MGI:1100494 (MGI) 319955 (Entrez Gene) Gene Tree Ercc6 (Alliance of Genome Resources)	Chr14 19.4 cM	Chr14:32235478-32302947 (+) GRCm39	Cockayne syndrome	ENSMUSG00000054051 (Ensembl Gene Model) ENSMUSP00000066256 (Ensembl) ENSMUST00000066807 (Ensembl)
rat	Ercc6	RGD:1311509 (Rat Genome Database) 306274 (Entrez Gene) Ercc6 (Alliance of Genome Resources)	Chr16 p16			NP_001100766 (RefSeq) NM_001107296 (RefSeq)
zebrafish	ercc6	ZDB-GENE-070228-1 (Zebrafish Model Organism Database) 560477 (Entrez Gene) ercc6 (Alliance of Genome Resources)	Chr13			XP_688972 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.