Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	ACTC1	HGNC:143 (HGNC) 70 (Entrez Gene) 102540 (OMIM) ACTC1 (Alliance of Genome Resources)	Chr15 q14	Chr15:34790107-34795589 (-) GRCh38	atrial heart septal defect 5 dilated cardiomyopathy dilated cardiomyopathy 1R hypertrophic cardiomyopathy 11	P68032 (UniProt | EBI) NM_001406485 (RefSeq)
mouse	Actc1	MGI:87905 (MGI) 11464 (Entrez Gene) Gene Tree Actc1 (Alliance of Genome Resources)	Chr2 57.55 cM	Chr2:113877763-113883356 (-) GRCm39	dilated cardiomyopathy 1R	11464 (NCBI Gene Model) P68033 (UniProt | EBI) NM_009608 (RefSeq)
rat	Actc1	RGD:2026 (Rat Genome Database) 29275 (Entrez Gene) Actc1 (Alliance of Genome Resources)	Chr3 q35			P68035 (UniProt | EBI) NM_019183 (RefSeq)
zebrafish	actc1a	ZDB-GENE-040520-4 (Zebrafish Model Organism Database) 408256 (Entrez Gene) actc1a (Alliance of Genome Resources)	Chr20			NP_001001409 (RefSeq) NM_001001409 (RefSeq)
	actc1b	ZDB-GENE-000322-1 (Zebrafish Model Organism Database) 58114 (Entrez Gene) actc1b (Alliance of Genome Resources)	Chr17			NP_571666 (RefSeq) NM_131591 (RefSeq)
	actc2	ZDB-GENE-040625-35 (Zebrafish Model Organism Database) 570210 (Entrez Gene) actc2 (Alliance of Genome Resources)	Chr20			NP_001002066 (RefSeq) NM_001002066 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.