Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	TOP3A	HGNC:11992 (HGNC) 7156 (Entrez Gene) 601243 (OMIM) TOP3A (Alliance of Genome Resources)	Chr17 p11.2	Chr17:18271428-18315007 (-) GRCh38	autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5	Q13472 (UniProt | EBI) NM_001320759 (RefSeq)
mouse	Top3a	MGI:1197527 (MGI) 21975 (Entrez Gene) Gene Tree Top3a (Alliance of Genome Resources)	Chr11 37.81 cM	Chr11:60630884-60668191 (-) GRCm39		ENSMUSG00000002814 (Ensembl Gene Model) ENSMUSP00000002891 (Ensembl) ENSMUST00000002891 (Ensembl)
rat	Top3a	RGD:1309320 (Rat Genome Database) 303194 (Entrez Gene) Top3a (Alliance of Genome Resources)	Chr10 q22			NP_001414385 (RefSeq) NM_001427456 (RefSeq)
zebrafish	top3a	ZDB-GENE-071212-2 (Zebrafish Model Organism Database) 560212 (Entrez Gene) top3a (Alliance of Genome Resources)	Chr3			XP_688695 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.