Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	LEPR	HGNC:6554 (HGNC) 3953 (Entrez Gene) 601007 (OMIM) LEPR (Alliance of Genome Resources)	Chr1 p31.3	Chr1:65420652-65641559 (+) GRCh38	chronic obstructive pulmonary disease coronary artery disease dilated cardiomyopathy hepatocellular carcinoma hypertension metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease obesity obstructive sleep apnea osteoporosis type 2 diabetes mellitus	P48357 (UniProt | EBI) NM_001003680 (RefSeq)
mouse	Lepr	MGI:104993 (MGI) 16847 (Entrez Gene) Gene Tree Lepr (Alliance of Genome Resources)	Chr4 46.96 cM	Chr4:101574601-101672549 (+) GRCm39	metabolic dysfunction-associated steatotic liver disease obesity type 2 diabetes mellitus	ENSMUSG00000057722 (Ensembl Gene Model) ENSMUSP00000037385 (Ensembl) ENSMUST00000037552 (Ensembl)
rat	Lepr	RGD:3001 (Rat Genome Database) 24536 (Entrez Gene) Lepr (Alliance of Genome Resources)	Chr5 q33			Q62959 (UniProt | EBI) NM_001429462 (RefSeq)
zebrafish	lepr	ZDB-GENE-080104-1 (Zebrafish Model Organism Database) 567241 (Entrez Gene) lepr (Alliance of Genome Resources)	Chr6			NP_001296332 (RefSeq) NM_001309403 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.