Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	NOTCH1	HGNC:7881 (HGNC) 4851 (Entrez Gene) 190198 (OMIM) NOTCH1 (Alliance of Genome Resources)	Chr9 q34.3	Chr9:136494433-136546048 (-) GRCh38	Adams-Oliver syndrome adult T-cell leukemia/lymphoma aortic valve disease 1 congenital heart disease	P46531 (UniProt | EBI) NM_017617 (RefSeq)
mouse	Notch1	MGI:97363 (MGI) 18128 (Entrez Gene) Gene Tree Notch1 (Alliance of Genome Resources)	Chr2 18.91 cM	Chr2:26347914-26393834 (-) GRCm39		18128 (NCBI Gene Model) Q01705 (UniProt | EBI) NM_008714 (RefSeq)
rat	Notch1	RGD:3187 (Rat Genome Database) 25496 (Entrez Gene) Notch1 (Alliance of Genome Resources)	Chr3 p13			Q07008 (UniProt | EBI) NM_001105721 (RefSeq)
zebrafish	notch1a	ZDB-GENE-990415-173 (Zebrafish Model Organism Database) 30718 (Entrez Gene) notch1a (Alliance of Genome Resources)	Chr21			P46530 (UniProt | EBI) NM_131441 (RefSeq)
	notch1b	ZDB-GENE-990415-183 (Zebrafish Model Organism Database) 794892 (Entrez Gene) notch1b (Alliance of Genome Resources)	Chr5			NP_571377 (RefSeq) NM_131302 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.