Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	BMP4	HGNC:1071 (HGNC) 652 (Entrez Gene) 112262 (OMIM) BMP4 (Alliance of Genome Resources)	Chr14 q22.2	Chr14:53949736-53958761 (-) GRCh38	atrial heart septal defect CAKUT CAKUT2 cartilage disease cleft lip melanoma orofacial cleft 11 ossification of the posterior longitudinal ligament of spine otosclerosis syndromic microphthalmia 6 tooth agenesis	P12644 (UniProt | EBI) NM_001347915 (RefSeq)
mouse	Bmp4	MGI:88180 (MGI) 12159 (Entrez Gene) Gene Tree Bmp4 (Alliance of Genome Resources)	Chr14 23.95 cM	Chr14:46620982-46628126 (-) GRCm39	atrioventricular septal defect Axenfeld-Rieger syndrome type 3 cleft palate-lateral synechia syndrome fibrodysplasia ossificans progressiva physical disorder urinary system disease	12159 (NCBI Gene Model) P21275 (UniProt | EBI) NM_007554 (RefSeq)
rat	Bmp4	RGD:2213 (Rat Genome Database) 25296 (Entrez Gene) Bmp4 (Alliance of Genome Resources)	Chr15 p14			Q06826 (UniProt | EBI) NM_012827 (RefSeq)
zebrafish	bmp4	ZDB-GENE-980528-2059 (Zebrafish Model Organism Database) 30612 (Entrez Gene) bmp4 (Alliance of Genome Resources)	Chr17			NP_571417 (RefSeq) NM_131342 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.