Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	CDK4	HGNC:1773 (HGNC) 1019 (Entrez Gene) 123829 (OMIM) CDK4 (Alliance of Genome Resources)	Chr12 q14.1	Chr12:57747727-57756013 (-) GRCh38	breast carcinoma familial melanoma glioblastoma lung non-small cell carcinoma obesity pancreatic adenocarcinoma prostate cancer type 2 diabetes mellitus urinary bladder cancer	P11802 (UniProt | EBI) NM_000075 (RefSeq)
mouse	Cdk4	MGI:88357 (MGI) 12567 (Entrez Gene) Gene Tree Cdk4 (Alliance of Genome Resources)	Chr10 74.5 cM	Chr10:126899404-126903157 (+) GRCm39	type 1 diabetes mellitus	12567 (NCBI Gene Model) P30285 (UniProt | EBI) NM_009870 (RefSeq)
rat	Cdk4	RGD:621120 (Rat Genome Database) 94201 (Entrez Gene) Cdk4 (Alliance of Genome Resources)	Chr7 q22			P35426 (UniProt | EBI) NM_053593 (RefSeq)
zebrafish	cdk4	ZDB-GENE-060929-974 (Zebrafish Model Organism Database) 777730 (Entrez Gene) cdk4 (Alliance of Genome Resources)	Chr11			NP_001071245 (RefSeq) NM_001423771 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.