Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	CYP2D6	HGNC:2625 (HGNC) 1565 (Entrez Gene) 124030 (OMIM) CYP2D6 (Alliance of Genome Resources)	Chr22 q13.2	Chr22:42126499-42130865 (-) GRCh38	acute lymphoblastic leukemia acute myeloid leukemia asthma autoimmune hepatitis extrapyramidal and movement disease head and neck squamous cell carcinoma major depressive disorder opiate dependence rhinitis	P10635 (UniProt | EBI) NM_000106 (RefSeq)
	CYP2D7	HGNC:2624 (HGNC) 1564 (Entrez Gene) CYP2D7 (Alliance of Genome Resources)	Chr22 q13.2	Chr22:42139576-42149455 (-) GRCh38		A0A087X1C5 (UniProt | EBI) NM_001348386 (RefSeq)
mouse	Cyp2d11	MGI:88603 (MGI) 545123 (Entrez Gene) Gene Tree Cyp2d11 (Alliance of Genome Resources)	Chr15 38.58 cM	Chr15:82273355-82278223 (-) GRCm39		545123 (NCBI Gene Model) P24457 (UniProt | EBI) NM_001104531 (RefSeq)
rat	Cyp2d1	RGD:708427 (Rat Genome Database) 266684 (Entrez Gene) Cyp2d1 (Alliance of Genome Resources)	Chr7 q34			P10633 (UniProt | EBI) NM_153313 (RefSeq)
	Cyp2d5	RGD:628630 (Rat Genome Database) 286963 (Entrez Gene) Cyp2d5 (Alliance of Genome Resources)	Chr7 q34			P12939 (UniProt | EBI) NM_173304 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.