Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	DEFA1	HGNC:2761 (HGNC) 1667 (Entrez Gene) 125220 (OMIM) DEFA1 (Alliance of Genome Resources)	Chr8 p23.1	Chr8:6977649-6980092 (-) GRCh38		P59665 (UniProt | EBI) NM_004084 (RefSeq)
	DEFA1B	HGNC:33596 (HGNC) 728358 (Entrez Gene) DEFA1B (Alliance of Genome Resources)	Chr8 p23.1	Chr8:6996766-6999198 (-) GRCh38		P59665 (UniProt | EBI) NM_001302265 (RefSeq)
	DEFA3	HGNC:2762 (HGNC) 1668 (Entrez Gene) 604522 (OMIM) DEFA3 (Alliance of Genome Resources)	Chr8 p23.1	Chr8:7015869-7018297 (-) GRCh38		P59666 (UniProt | EBI) NM_005217 (RefSeq)
	DEFA5	HGNC:2764 (HGNC) 1670 (Entrez Gene) 600472 (OMIM) DEFA5 (Alliance of Genome Resources)	Chr8 p23.1	Chr8:7055304-7056739 (-) GRCh38		Q01523 (UniProt | EBI) NM_021010 (RefSeq)
	DEFA6	HGNC:2765 (HGNC) 1671 (Entrez Gene) 600471 (OMIM) DEFA6 (Alliance of Genome Resources)	Chr8 p23.1	Chr8:6924697-6926076 (-) GRCh38		Q01524 (UniProt | EBI) NM_001926 (RefSeq)
mouse	Defa28	MGI:3646688 (MGI) 626682 (Entrez Gene) Gene Tree Defa28 (Alliance of Genome Resources)	Chr8 10.35 cM	Chr8:22072976-22073883 (+) GRCm39		626682 (NCBI Gene Model) NP_001170994 (RefSeq) NM_001177523 (RefSeq)
rat	Defa24	RGD:1304852 (Rat Genome Database) 290856 (Entrez Gene) Defa24 (Alliance of Genome Resources)	Chr16 q12.5			P82106 (UniProt | EBI) NM_001013053 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.