Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	CFB	HGNC:1037 (HGNC) 629 (Entrez Gene) 138470 (OMIM) CFB (Alliance of Genome Resources)	Chr6 p21.33	Chr6:31945650-31952086 (+) GRCh38	acute lymphoblastic leukemia age related macular degeneration 14 anterior uveitis atypical hemolytic-uremic syndrome diabetic retinopathy IgA glomerulonephritis macular degeneration membranoproliferative glomerulonephritis membranous glomerulonephritis psoriasis sickle cell anemia type 1 diabetes mellitus	P00751 (UniProt | EBI) NM_001710 (RefSeq)
mouse	Cfb	MGI:105975 (MGI) 14962 (Entrez Gene) Gene Tree Cfb (Alliance of Genome Resources)	Chr17 18.41 cM	Chr17:35075350-35081492 (-) GRCm39		14962 (NCBI Gene Model) P04186 (UniProt | EBI) NM_001402875 (RefSeq)
zebrafish	bfb	ZDB-GENE-990415-34 (Zebrafish Model Organism Database) 30489 (Entrez Gene) bfb (Alliance of Genome Resources)	Chr21			NP_571316 (RefSeq) NM_131241 (RefSeq)
	cfb	ZDB-GENE-980526-487 (Zebrafish Model Organism Database) 30604 (Entrez Gene) cfb (Alliance of Genome Resources)	Chr21			NP_571413 (RefSeq) NM_131338 (RefSeq)
	cfbl	ZDB-GENE-030131-2319 (Zebrafish Model Organism Database) 792472 (Entrez Gene) cfbl (Alliance of Genome Resources)	Chr21			NP_001077327 (RefSeq) NM_001083858 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.