Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SH2B3	HGNC:29605 (HGNC) 10019 (Entrez Gene) 605093 (OMIM) SH2B3 (Alliance of Genome Resources)	Chr12 q24.12	Chr12:111404730-111451623 (+) GRCh38	colorectal cancer essential thrombocythemia familial erythrocytosis 1 myelofibrosis type 1 diabetes mellitus	Q9UQQ2 (UniProt | EBI) NM_001291424 (RefSeq)
mouse	Sh2b3	MGI:893598 (MGI) 16923 (Entrez Gene) Gene Tree Sh2b3 (Alliance of Genome Resources)	Chr5 61.99 cM	Chr5:121953551-121975709 (-) GRCm39	chronic myeloid leukemia	ENSMUSG00000042594 (Ensembl Gene Model) ENSMUSP00000083490 (Ensembl) ENSMUST00000086310 (Ensembl)
rat	Sh2b3	RGD:68411 (Rat Genome Database) 58838 (Entrez Gene) Sh2b3 (Alliance of Genome Resources)	Chr12 q16			P50745 (UniProt | EBI) NM_031621 (RefSeq)
zebrafish	sh2b3	ZDB-GENE-041210-359 (Zebrafish Model Organism Database) 101884640 (Entrez Gene) sh2b3 (Alliance of Genome Resources)	Chr5			XP_017211718 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.