Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	RUNX2	HGNC:10472 (HGNC) 860 (Entrez Gene) 600211 (OMIM) RUNX2 (Alliance of Genome Resources)	Chr6 p21.1	Chr6:45328157-45664349 (+) GRCh38	cleidocranial dysplasia lung non-small cell carcinoma metaphyseal dysplasia-maxillary hypoplasia-brachydactyly syndrome	Q13950 (UniProt | EBI) NM_001369405 (RefSeq)
mouse	Runx2	MGI:99829 (MGI) 12393 (Entrez Gene) Gene Tree Runx2 (Alliance of Genome Resources)	Chr17 21.33 cM	Chr17:44806873-45125518 (-) GRCm39	cleidocranial dysplasia congenital hypothyroidism	12393 (NCBI Gene Model) Q08775 (UniProt | EBI) NM_001271627 (RefSeq)
rat	Runx2	RGD:2282 (Rat Genome Database) 367218 (Entrez Gene) Runx2 (Alliance of Genome Resources)	Chr9 q13			Q9Z2J9 (UniProt | EBI) NM_001278484 (RefSeq)
zebrafish	runx2a	ZDB-GENE-040629-3 (Zebrafish Model Organism Database) 405784 (Entrez Gene) runx2a (Alliance of Genome Resources)	Chr17			NP_998023 (RefSeq) NM_212858 (RefSeq)
	runx2b	ZDB-GENE-040629-4 (Zebrafish Model Organism Database) 405788 (Entrez Gene) runx2b (Alliance of Genome Resources)	Chr20			NP_998027 (RefSeq) NM_212862 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.