Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	RYR1	HGNC:10483 (HGNC) 6261 (Entrez Gene) 180901 (OMIM) RYR1 (Alliance of Genome Resources)	Chr19 q13.2	Chr19:38433691-38595273 (+) GRCh38	congenital myopathy 1A congenital myopathy 1B congestive heart failure intracranial vasospasm King Denborough syndrome malignant hyperthermia primary pulmonary hypertension	P21817 (UniProt | EBI) NM_001042723 (RefSeq)
mouse	Ryr1	MGI:99659 (MGI) 20190 (Entrez Gene) Gene Tree Ryr1 (Alliance of Genome Resources)	Chr7 16.94 cM	Chr7:28702765-28824599 (-) GRCm39	congenital myopathy 1A congenital myopathy 1B malignant hyperthermia	20190 (NCBI Gene Model) E9PZQ0 (UniProt | EBI) NM_009109 (RefSeq)
rat	Ryr1	RGD:1586637 (Rat Genome Database) 114207 (Entrez Gene) Ryr1 (Alliance of Genome Resources)	Chr1 q21			F1LMY4 (UniProt | EBI) NM_001419537 (RefSeq)
zebrafish	ryr1a	ZDB-GENE-020108-2 (Zebrafish Model Organism Database) 798565 (Entrez Gene) ryr1a (Alliance of Genome Resources)	Chr10			XP_068079935 (RefSeq)
	ryr1b	ZDB-GENE-070705-417 (Zebrafish Model Organism Database) 570245 (Entrez Gene) ryr1b (Alliance of Genome Resources)	Chr18			NP_001096041 (RefSeq) NM_001102571 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.