Phenotype Image Detail

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Caption

Harlequin mice exhibit paucity of fur resulting in near baldness in hemizygous males and homozygous females. Ataxia is noticeable by 5 months and progresses as the mice age. Initially the ataxia manifests itself as a side-to-side, unsteady gait with a lateral tremor visible at rest. Cell loss is greater in the caudal lobules of the cerebellum and is extensive by 9 to 11 months of age. Retinal degeneration is found beginning with ganglion and amacrine cell loss in the ganglion cell layer at 3 months of age, and progresses with cell loss in the inner and outer nuclear layers and reduction of rod and cone ERG responses at 4 months of age. By 10 months, the rod and cone ERG responses are gone, and at 11 months of age there isapparent cell loss in all layers of the retina.

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Photo donated for Mouse Genome Informatics Database use. J:110244

Associated Alleles

Symbol	Name
Aifm1^Hq	apoptosis-inducing factor, mitochondrion-associated 1; harlequin