Phenotype Image Detail

Image

Caption

Morphologic analysis of MPD. Peripheral blood and bone marrow slides show evidence of myeloid hyperplasia with loss of erythroid and lymphoid precursors in the bone marrow and polychromasia in peripheral blood of Ly6a^{tm2(RUNX1)Grau}/Ly6a⁺ mice compared with wild type littermates. In the spleen, increased extramedullary hematopoiesis disrupts the follicular architecture.

Copyright

This image is from Fenske TS, Proc Natl Acad Sci U S A 2004 Nov 19;101(42):15184-9. Copyright 2004 National Academy of Sciences, U.S.A. J:93408

Associated Alleles

Symbol	Name
Ly6a^tm2(RUNX1)Grau	lymphocyte antigen 6 family member A; targeted mutation 2, Timothy A Graubert

Associated Genotypes

Allelic Composition	Genetic Background
Ly6a^tm2(RUNX1)Grau/Ly6a^+	involves: 129X1/SvJ * C57BL/6J