Phenotype Image Detail

Image

Caption

Aft/Aft⁺ mice are recognizable by tail kinks(Panel A) and partial sydactyly of the third and fourth digits of the hind feet (Panel B). The syndactyly does not result from bone fusion but from the persistence of the skin web which normally is removed via apoptosis during development. (Panel C). Tailkinks are a result of a varying degrees of overgrowth and fusion of cartilage and a corresponding dysmorphogenesis of bony elements attached to fusion site. (Panel D). Between 6-8 months of age Aft/Aft⁺ mice develop hairloss behind the ears and snout as well as a clumpy and unkempt appearance of fur, which over time progresses into bleeding ulcerations (Panel E).

Copyright

This image is from Ruvinsky I, Mamm Genome 2002 Dec;13(12):675-9 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:81166

Associated Alleles

Symbol	Name
Aft	abnormal feet and tail

Associated Genotypes

Allelic Composition	Genetic Background
Aft/Aft^+	involves: 129S1/Sv * C57BL/6J